After your subject has ingested an isotopically labelled meal (e.g. 13C-labelled glucose), exhaled CO2 from the patient will show enrichment in 13C levels relative to 12C. The time taken for the 13C isotope to appear in the exhaled breath gives some indication of the metabolic rate of the subject. Up to 220 breath samples can be analysed using our iso FLOW sample handling system for rapid analysis of large numbers of samples.
Dosing a subject (human or animal) with doubly labelled water (e.g. water enriched in both deuterium and 18O) allows the total energy expenditure (TEE) of the subject to be determined. High performance deuterium and 18O isotope analysis of up to 180 saliva, blood and urine samples can be performed via headspace equilibration using the iso FLOW sample handling system.
To understand more about the complex physiological chemical processes that occur within the body, it is necessary to go beyond coarse breath and body fluid analysis. Our gas and liquid chromatography (GC-IRMS and LC-IRMS) systems are able to perform individual compound stable isotope analysis allowing you to find out more about these complex processes.
Our customers use our instruments to do some amazing research in the medical application field. To show you how they perform their research and how they use our IRMS instruments, we have collected a range of peer-reviewed publications which cite our products. You can find the citations below and then follow the links to the publishing journal should you wish to download the publication.
If you would like to investigate our available citations in more detail, or email the citation list to yourself or your colleagues then take a look at our full citation database.